people, Internet, Entrepreneurship Robert Buderi wrote: For entrepreneurs and investors alike, it was a sad day back in January, when Y Combinator founder Paul Graham announced he would stay in Silicon Valley year round and give up splitting his startup incubation activities between Mountain View an...

Biotech, cancer, Drugs Luke Timmerman wrote: Nowhere but America makes it possible for a company to pursue its dreams for 28 years without making a profit. Even in the most optimistic times, it’s hard to explain. So how can it possibly be, in the depths of recession, that things are looking up...

IT, internet video, Media Wade Roush wrote: These days, there’s no sense in producing video for just one platform, like cable TV. Media companies also want to get their content out to consumers via the Web, mobile phones, game consoles, video-on-demand networks, and other platforms. The proble...

IT, Storage, startups Wade Roush wrote: If you ate on your best china every night, flew first class even on puddle jumpers, and habitually drove your Mercedes rather than your minivan to the grocery store, it would be a lot like what most big companies do with their data, according to Tom Cook. More...

internet video, Barack Obama, Privacy Wade Roush wrote: Rather than sending President Obama’s weekly Web video address to YouTube for hosting, as it has in past weeks, the White House published last Saturday’s video on its own website, Whitehouse.gov, which is hosted by Akamai. But an Ak...

IT, startups, Search Wade Roush wrote: Sometimes (just sometimes) it pays to look behind the jargon in press releases. One glance at yesterday’s coming-out-of-stealth-mode announcement from Boxborough, MA-based Digital Reef, which starts off talking about “massively scalable unstructured...

Biotech, FDA, Life Sciences Luke Timmerman wrote: Genzyme got some bad news today from the FDA. The Cambridge, MA-based biotech company said that U.S. regulators determined its drug for Pompe disease made in large-scale vats isn’t ready to be approved for the market. Plus, the FDA sent the com...

urban planning, Kendall Square, Cambridge Wade Roush wrote: Companies, merchants, and residents in the Kendall Square neighborhood of Cambridge banded together last week to form the Kendall Square Association, a non-profit group whose mission, according to its new president Tim Rowe, is to “im...

innovation, IT, Massachusetts Robert Buderi wrote: Unless you’ve been on an innovation vacation in recent months, it’s been hard to miss all the talk here in Massachusetts about finding a new “brand” for the state’s IT community—you know, as a way to compete with ...

Biotech, cancer, Melanoma Luke Timmerman wrote: Synta Pharmaceuticals reported some disastrous news this afternoon. The Lexington, MA-based biotech company (NASDAQ: SNTA) said it has halted a clinical trial involving more than 630 cancer patients because a greater number of people died after taking ...